Leading Sires of 2021 Grade I Stakes Winners
(through 31 December 2021)
| Rank | Stallion | Sire | Location | SWs |
| 1 | DEEP IMPACT | SUNDAY SILENCE | DEAD | 10 |
| 2 | CURLIN | SMART STRIKE | KY | 5 |
| FRANKEL | GALILEO | ENG | 5 | |
| 4 | DUBAWI | DUBAI MILLENNIUM | ENG | 4 |
| GALILEO | SADLER'S WELLS | DEAD | 4 | |
| INTO MISCHIEF | HARLAN'S HOLIDAY | KY | 4 | |
| 7 | DARK ANGEL | ACCLAMATION | IRE | 3 |
| ENGLISH CHANNEL | SMART STRIKE | DEAD | 3 | |
| KINGMAN | INVINCIBLE SPIRIT | ENG | 3 | |
| MUNNINGS | SPEIGHTSTOWN | KY | 3 | |
| POWER | OASIS DREAM | UNK | 3 | |
| TWIRLING CANDY | CANDY RIDE | KY | 3 | |